Trolox

Name: Trolox
Brand: Tocris Bioscience
SKU: 6002

Tocris Bioscience, part of Bio-Techne | Catalog # 6002

Citations (18)

COA / SDS

Antifade reagent; antioxidant vitamin E derivative; cell permeable and water soluble

Key Product Details

Chemical Name:	3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Purity:	≥98%

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Technical Data
Citations

Biological Activity for Trolox

Trolox is an antioxidant vitamin E derivative; suppresses osteoclast formation and inhibits IL-1-induced osteoclast bone loss. Also inhibits ferroptosis. Commonly used antifade reagent in live cell imaging; suppresses blinking and photobleaching. Cell-permeable and water soluble.

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Technical Data for Trolox

Formula	C₁₄H₁₈O₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	53188-07-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Trolox

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

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References for Trolox

References are publications that support the biological activity of the product.

Giulivi et al. Inhibition of protein radical reactions of ferrylmyoglobin by the water-soluble analog of vitamin E, Trolox C. Arch.Biochem.Biophys., 1993;303:152 PMID: 8489259
Lee et al. Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling. J.Biol.Chem., 2009;284:13725 PMID: 19299513
Xie et al. Ferroptosis: process and function. Cell.Death.Differ, 2016;23:369 PMID: 26794443
Cordes et al. On the mechanism of Trolox as antiblinking and antibleaching reagent. J.Am.Chem.Soc., 2009;131:5018 PMID: 19301868