Recombinant Mouse B7-1/CD80 Protein
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26578
Key Product Details
Source
Baculovirus
Conjugate
Unconjugated
Applications
Cell Depletion, SDS-PAGE
Product Specifications
Description
A recombinant protein corresponding to CD80.
Amino Acid Sequence: MGHTRRQGTSPSKCPYLNFFQLLVLAGLSHFCSGVIHVTKEVKEVATL
SCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDI
TNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPT
PSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETEL
YAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDDKTHT
CPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYV
DGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKV
SNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDI
AVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVM
HEALHNHYTQKSLSLSPGK
Extracellular domain (amino acids 1-241) of human B7.1 sequence is underlined.
Human Fc sequence is in italics.
Purity
Protein A purified
Endotoxin Level
Endotoxin level < 0.1 EU/ug of the protein (< 0.01 ng/ug of the protein) as determined by the LAL test.
Predicted Molecular Mass
66 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Activity
Can be used as an effective anti-tumor agent in combinantion with Treg depletion. May block binding of membrane bound B7.1 with its receptors, CD28 and CTLA-4, thereby sustaining the activation of tumor specific T cells or preventing their down regulation.
Application Notes
Can be used as an effective anti-tumor agent in combinantion with Treg depletion. May block binding of membrane bound B7.1 with its receptors, CD28 and CTLA-4, thereby sustaining the activation of tumor specific T cells or preventing their down regulation
Protein / Peptide Type
Recombinant Protein
Scientific Data Images for Recombinant Mouse B7-1/CD80 Protein
![SDS-PAGE: Recombinant Mouse B7-1/CD80 Protein [NBP2-26578]](https://resources.bio-techne.com/images/products/Recombinant-Mouse-B7-1-CD80-Protein-SDS-Page-NBP2-26578-img0002.jpg "SDS-PAGE: Recombinant Mouse B7-1/CD80 Protein [NBP2-26578]")
SDS-PAGE: Recombinant Mouse B7-1/CD80 Protein [NBP2-26578]
SDS-Page: Recombinant Mouse B7-1/CD80 Protein [NBP2-26578] - SDS-PAGE analysis of recombinant B7.1-Fc to demonstrate purity of protein.
Bioactivity: Recombinant Mouse B7-1/CD80 Protein [NBP2-26578] - Effect of B7.1-Fc on the growth of tumor cells. B7.1-Fc fusion protein prevents growth of mouse solid tumor, RENCA. The immunotherapy is more more effective in combination with CD25+ depletion and B7.1-Fc fusion protein (PMID: 16322313)
Formulation, Preparation and Storage
NBP2-26578
| Formulation | Phosphate-buffered solution, pH 7.2, containing no preservative. 0.2 um filter sterilized. |
| Concentration | 2.0 mg/ml |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at -80C. Avoid freeze-thaw cycles. |
Background: B7-1/CD80
Alternate Names
B71, CD80
Gene Symbol
CD80
Additional B7-1/CD80 Products
Product Documents for Recombinant Mouse B7-1/CD80 Protein
Product Specific Notices for Recombinant Mouse B7-1/CD80 Protein
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
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