Recombinant Human CCL17/TARC Protein

Name: Recombinant Human CCL17/TARC Protein
Brand: Novus Biologicals
SKU: NBP2-35037

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-35037

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Product Datasheet / COA

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Product Specifications
Preparation & Storage
Background
Product Documents
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Key Product Details

Source

E. coli

Accession #

Q92583

Conjugate

Unconjugated

Applications

Bioactivity, SDS-PAGE

View all CCL17/TARC Proteins and Enzymes »

Product Specifications

Description

A single non-glycosylated polypeptide chain containing 71 amino acids corresponding to CCL17/TARC Source: E. coli

Uniprot ID: Q92583

Amino Acid Sequence: ARGTNVGREC CLEYFKGAIP LRKLKTWYQT SEDCSRDAIV FVTVQGRAIC SDPNNKRVKN AVKYLQSLER S

Purity

> 97 % pure by SDS-PAGE and HPLC

Endotoxin Level

Less than 1 EU/ug of CCL17/TARC as determined by LAL method.

Predicted Molecular Mass

8.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Activity

Thymus protein is fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.

Protein / Peptide Type

Recombinant Protein

Formulation, Preparation and Storage

NBP2-35037

Formulation	Lyophilized from a 0.2 um filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.
Preservative	No Preservative
Concentration	Lyoph
Reconstitution	Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL.
Format	Carrier-Free
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles.

Background: CCL17/TARC

Human CCL17 also known as thymus and activation-related chemokine (TARC) is encoded by the CCL17 gene located on the chromosome 16 in humans. It is expressed by thymus cells constitutively and phytohemagglutinin-stimulated peripheral blood mononuclear cells transiently. CCL17 signals through the chemokine receptors CCR4 and CCR8 and displays chemotactic activity for T lymphocytes and some other leukocytes. It plays an important role in skin diseases such as atopic dermatitis, bullous pemphigoid and mycosis fungoides. CCL17 has approximately 24 - 29 % amino acid sequence identity with RANTES, MIP-1alpha, MIP-1beta, MCP-1, MCP-2, MCP-3 and I-309.

Alternate Names

ABCD-2, SCYA17, TARC

Gene Symbol

CCL17

UniProt