CD11b/c Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NB110-40766PEP

Novus Biologicals, part of Bio-Techne
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NB110-40766PEP
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Key Product Details

Conjugate

Unconjugated

Applications

Antibody Competition

View all CD11b/c Proteins and Enzymes »

Product Specifications

Description

A ITGAM antibody blocking peptide.

Application Notes

This peptide is useful as a blocking peptide for NB110-40766. For further blocking peptide related protocol, click here.

Specificity

This peptide is specific for NB110-40766 only.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NB110-40766PEP
Formulation Peptide dissolved in dH2O. Contains no BSA.
Preservative No Preservative
Concentration 1.0 mg/ml
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -80C. Avoid freeze-thaw cycles.

Background: CD11b/c

CD11b, also known as Integrin alpha M, is one half of the heterodimeric integrin alpha-M beta-2 molecule. This protein mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. CD11b is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. Mutations in the CD11b protein have been assosicated with the autoimmune disease lupus, and CD11b antibodies are therefore commonly in immunology studies.

CD11c, also known as Integrin alpha X, is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst; expressed in hairy cell leukemias, acute nonlymphocytic leukemias, and some B-cell chronic lymphocytic leukemias.

Alternate Names

antigen CD11b (p170), CD11 antigen-like family member B, CD11b, CD11b antigen, CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide), Cell surface glycoprotein MAC-1 subunit alpha, CR-3 alpha chain, CR3AMGC117044, integrin alpha-M, integrin, alpha M (complement component 3 receptor 3 subunit), Leukocyte adhesion receptor MO1, MAC-1, MAC1A, macrophage antigen alpha polypeptide, MO1A, Neutrophil adherence receptor, neutrophil adherence receptor alpha-M subunit, SLEB6

Gene Symbol

ITGAM

Additional CD11b/c Products

Product Documents for CD11b/c Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CD11b/c Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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