DOK1 Antibody Blocking Peptide

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-77064PEP

Novus Biologicals, part of Bio-Techne
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NBP1-77064PEP
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Key Product Details

Source

Synthetic

Conjugate

Unconjugated

Applications

Antibody Competition

View all DOK1 Proteins and Enzymes »

Product Specifications

Description

A blocking peptide containing 15 amino acids near the carboxy terminus of human DOK.

Source: Synthetic

(Accession #: AAC51127)

Purity

N/A

Application Notes

This peptide is useful as a blocking peptide for NBP1-77064.

For further blocking peptide related protocol, click here.

Protein / Peptide Type

Antibody Blocking Peptide

Formulation, Preparation and Storage

NBP1-77064PEP
Formulation PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
Preservative 0.02% Sodium Azide
Concentration 0.2 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at -20C. Avoid freeze-thaw cycles.

Background: DOK1

Dok-1 associates with the Ras GTPase-activating protein (Ras GAP) upon tyrosine phosphorylation. Evidence suggests that Dok-1 (also designated p62dok) is a substrate of the constitutive tyrosine kinase activity of p210 Bcr-Abl, a fusion protein caused by the t(9;22) translocation and associated with chronic myelogenous leukemia. Dok-1, as well as the tyrosine kinase substrates IRS-1 and Cas, are members of a class of "docking" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 is suspected to be the substrate phosphorylated in response to stimulation by a number of growth factors, including PDGF, VEGF, insulin and IGF. Dok-2 (also designated p56dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl.

Alternate Names

docking protein 1, docking protein 1 (downstream of tyrosine kinase 1), docking protein 1, 62kD (downstream of tyrosine kinase 1), docking protein 1, 62kDa (downstream of tyrosine kinase 1), Downstream of tyrosine kinase 1, MGC117395, MGC138860, p62(dok), p62dok, pp62

Gene Symbol

DOK1

Additional DOK1 Products

Product Documents for DOK1 Antibody Blocking Peptide

Product Datasheets

Certificate of Analysis

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Product Specific Notices for DOK1 Antibody Blocking Peptide

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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