Recombinant Human eIF2B1 His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51089

Novus Biologicals, part of Bio-Techne
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Key Product Details

Source

E. coli

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all eIF2B1 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-305 of Human eIF2B1

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL IKLYL

Purity

>90%, by SDS-PAGE

Predicted Molecular Mass

35.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human eIF2B1 His Protein

SDS-PAGE: Recombinant Human eIF2B1 His Protein [NBP1-51089]

SDS-PAGE: Recombinant Human eIF2B1 His Protein [NBP1-51089]

SDS-Page: Recombinant Human eIF2B1 Protein [NBP1-51089] - 15 % SDS-PAGE (3ug)

Formulation, Preparation and Storage

NBP1-51089
Formulation 20 mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.1 M NaCl
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: eIF2B1

EIF2B1 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Phosphorylation of eIF2 inhibits GEF activity of EIF2B, an inhibition that requires the eIF2B1 subunit. Defects in eIF2B1 are a cause of leukoencephalopathy with vanishing white matter (VWM), a brain disease that is characterized by head trauma and motor deterioration. Recombinant human EIF2B1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Alternate Names

EIF2B, EIF-2B, eIF-2B GDP-GTP exchange factor subunit alpha, EIF-2Balpha, EIF2BAMGC117409, eukaryotic translation initiation factor 2B, subunit 1 (alpha, 26kD), eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa, MGC125868, MGC125869, translation initiation factor eIF-2B subunit alpha

Gene Symbol

EIF2B1

Additional eIF2B1 Products

Product Documents for Recombinant Human eIF2B1 His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human eIF2B1 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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