Recombinant Mouse ErbB2/Her2 His (C-Term) Protein

Name: Recombinant Mouse ErbB2/Her2 His (C-Term) Protein
Brand: Novus Biologicals
SKU: NBP3-18206

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-18206

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Source

HEK293

Tag

His (C-Term)

Conjugate

Unconjugated

Applications

SDS-PAGE

View all ErbB2/Her2 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a C-terminal 6xHis tag corresponding to the amino acids Thr23-Thr653 of Mouse ErbB2/Her2.

Source: HEK293

(Accession #: NP_001003817.1)

Store at -20C to -80C long term. After reconstitution, the product is stable at -20C for 3 months, and 2-8C for up to 1 week.

Purity

>97%, by SDS-PAGE

Endotoxin Level

< 0.1 EU/ug of the protein by LAL method

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Mouse ErbB2/Her2 His (C-Term) Protein

SDS-PAGE: Recombinant Mouse ErbB2/Her2 His (C-Term) Protein [NBP3-18206]

SDS-Page: Recombinant Mouse ErbB2/Her2 His (C-Term) Protein [NBP3-18206] - Recombinant Mouse ErbB2/Her2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 100-110 kDa.

Formulation, Preparation and Storage

NBP3-18206

Formulation	Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4
Concentration	Lyoph
Reconstitution	Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at -20C.

Background: ErbB2/Her2

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Long Name

Receptor Tyrosine Protein Kinase ErbB2

Alternate Names

CD340, HER2, Neu Oncogene, NGL, TKR1

Gene Symbol

ERBB2

Additional ErbB2/Her2 Products

Product Documents for Recombinant Mouse ErbB2/Her2 His (C-Term) Protein

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COA

Product Specific Notices for Recombinant Mouse ErbB2/Her2 His (C-Term) Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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