Recombinant Human MAPKAP Kinase 3 His Protein

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-23246

Novus Biologicals, part of Bio-Techne
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NBP2-23246
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Key Product Details

Source

E. coli

Tag

His

Conjugate

Unconjugated

Applications

SDS-PAGE

View all MAPKAP Kinase 3 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-382 of Human MAPKAP Kinase 3

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDGETAE EQGGPVPPPV APGGPGLGGA PGGRREPKKY AVTDDYQLSK QVLGLGVNGK VLECFHRRTG QKCALKLLYD SPKARQEVDH HWQASGGPHI VCILDVYENM HHGKRCLLII MECMEGGELF SRIQERGDQA FTEREAAEIM RDIGTAIQFL HSHNIAHRDV KPENLLYTSK EKDAVLKLTD FGFAKETTQN ALQTPCYTPY YVAPEVLGPE KYDKSCDMWS LGVIMYILLC GFPPFYSNTG QAISPGMKRR IRLGQYGFPN PEWSEVSEDA KQLIRLLLKT DPTERLTITQ FMNHPWINQS MVVPQTPLHT ARVLQEDKDH WDEVKEEMTS ALATMRVDYD QVKIKDLKTS NNRLLNKRRK KQAGSSSASQ GCNNQ

Purity

>95%, by SDS-PAGE

Predicted Molecular Mass

45.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human MAPKAP Kinase 3 His Protein

SDS-PAGE: Recombinant Human MAPKAP Kinase 3 His Protein [NBP2-23246]

SDS-PAGE: Recombinant Human MAPKAP Kinase 3 His Protein [NBP2-23246]

SDS-Page: MAPKAP Kinase 3 Protein [NBP2-23246]

Formulation, Preparation and Storage

NBP2-23246
Formulation 20 mM Tris-HCl buffer (pH 8.0), 0.2 M NaCl, 20% glycerol, 1 mM DTT
Preservative No Preservative
Concentration 1 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: MAPKAP Kinase 3

MAP kinase-activated protein kinase 3, also known as MAPKAPK3, is involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Recombinant human MAPKAPK3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

3PKEC 2.7.11.1, Chromosome 3p kinase, EC 2.7.11, MAP kinase-activated protein kinase 3, MAPK-activated protein kinase 3, MAPKAP kinase 3, MAPKAP33pK, MAPKAPK-3, mitogen-activated protein kinase-activated protein kinase 3

Gene Symbol

MAPKAPK3

Additional MAPKAP Kinase 3 Products

Product Documents for Recombinant Human MAPKAP Kinase 3 His Protein

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human MAPKAP Kinase 3 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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