Recombinant Human Aminopeptidase LRAP/ERAP2 Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 3830-ZN
Key Product Details
Product Specifications
Source
Mouse myeloma cell line, NS0-derived human Aminopeptidase LRAP/ERAP2 protein
Ala56-Thr960, with an N-terminal 6-His tag
Ala56-Thr960, with an N-terminal 6-His tag
Purity
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
His
Predicted Molecular Mass
105 kDa
SDS-PAGE
122 kDa, reducing conditions
Activity
Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (Arg-AMC).
The specific activity is >50 pmol/min/µg, as measured under the described conditions.
The specific activity is >50 pmol/min/µg, as measured under the described conditions.
Formulation, Preparation and Storage
3830-ZN
| Formulation | Supplied as a 0.2 μm filtered solution in Tris, NaCl and Glycerol. |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: Aminopeptidase LRAP/ERAP2
Leukocyte-derived arginine aminopeptidase (LRAP) and endoplasmic reticulum-aminopeptidase 2 (ERAP2) are the two names given to the protein encoded by the LRAP gene (1, 2). Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors. It belongs to the oxytocinase subfamily of M1 aminopeptidases, which also includes aminopeptidases PILS/ARTS1/ERAP1 and LNPEP/PLAP (1, 3). In addition to antigen presentation, the members of this subfamily are also important in maintenance of pregnancy, memory retention, and blood pressure regulation (3).
References
- Tanioka, T. et al. (2003) J. Biol. Chem. 278:32275.
- Tanioka, T. et al. (2005) FEBS J. 272:916.
- Tsujimoto, M. and A. Hattori (2005) Biochim. Biophys. Acta 1751:9.
Long Name
Leukocyte-derived Arginine Aminopeptidase
Alternate Names
ERAP2
Entrez Gene IDs
64167 (Human)
Gene Symbol
ERAP2
UniProt
Additional Aminopeptidase LRAP/ERAP2 Products
Product Documents for Recombinant Human Aminopeptidase LRAP/ERAP2 Protein, CF
Product Specific Notices for Recombinant Human Aminopeptidase LRAP/ERAP2 Protein, CF
For research use only
Loading...
Loading...
Loading...