Recombinant Human CD79A Protein, CF

R&D Systems, part of Bio-Techne | Catalog # 9685-CD

R&D Systems, part of Bio-Techne
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9685-CD-050
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Key Product Details

Source

NS0

Accession #

P11912-1

Conjugate

Unconjugated

View all CD79A Proteins and Enzymes »

Product Specifications

Source

Mouse myeloma cell line, NS0-derived human CD79A protein
Leu33-Arg143, with a C-terminal 6-His tag

Purity

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

Endotoxin Level

<0.10 EU per 1 μg of the protein by the LAL method.

N-terminal Sequence Analysis

Leu33

Predicted Molecular Mass

13 kDa

SDS-PAGE

38-43 kDa, reducing conditions

Activity

Bioassay data are not available.

Scientific Data Images for Recombinant Human CD79A Protein, CF

Recombinant Human CD79A Protein SDS-PAGE

Recombinant Human CD79A Protein SDS-PAGE

2 μg/lane of Recombinant Human CD79A was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® blue staining, showing bands at 38 - 43 kDa.

Formulation, Preparation and Storage

9685-CD
Formulation Lyophilized from a 0.2 μm filtered solution in PBS and EDTA.
Reconstitution
Reconstitute at 250 μg/mL in PBS.

Reconstitution Buffer Available:
Size / Price
Qty
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CD79A

CD79A (also known as Mb-1, Ig alpha and B cell antigen receptor complex-associated protein alpha-chain) is a 30-40 kDa member of the Ig-Superfamily. It is expressed on B cells, and forms a covalent heterodimer with CD79B. Heterodimers of CD79A and CD79B interacts noncovalently with membrane Ig, forming the B cell antigen receptor (BCR) (1). Within this complex, membrane Ig detects antigen while CD79AB initiates signaling (1). CD79A is essential for the differentiation of pre-B cells, and the pre-BCR regulates the surface expression of IL-7R (2). Mature human CD79A is a type I transmembrane glycoprotein. It contains an extracellular region (aa 33-143) with one C2-type Ig-like domain (aa 33-116), and an ITAM-containing cytoplasmic domain (aa 177-205) (3). Within the ECD, human CD79A shares 57% amino acid sequence identity with mouse and rat CD79A.

References

  1. Tseng, J. et al. (1997) Blood, 89:1513.
  2. Kurosaki, T. (2000) Current opinion in immunology, 12:276.
  3. Radaev, Sergei et al. (2010) Structure 18:934.

Alternate Names

CD79A, MB-1

Entrez Gene IDs

973 (Human); 12518 (Mouse); 681236 (Rat); 722190 (Rhesus Macaque)

Gene Symbol

CD79A

UniProt

P11912-1

Additional CD79A Products

Product Documents for Recombinant Human CD79A Protein, CF

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Recombinant Human CD79A Protein, CF

For research use only

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