Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: TIMP-1

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Long Name

Tissue Inhibitors of Metalloproteinases 1

Alternate Names

TIMP1

Entrez Gene IDs

7076 (Human); 21857 (Mouse); 116510 (Rat)

Gene Symbol

TIMP1

Additional TIMP-1 Products

Product Documents for Recombinant Human TIMP-1 Western Blot Standard Protein

Product Datasheets

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COA

SDS

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Product Specific Notices for Recombinant Human TIMP-1 Western Blot Standard Protein

For research use only

Citations
Reviews

Recombinant Human TIMP-1 Western Blot Standard Protein

R&D Systems, part of Bio-Techne | Catalog # WBC021

Key Product Details

Source

Conjugate

Applications

View all TIMP-1 Proteins and Enzymes »

Formulation, Preparation and Storage

WBC021