Recombinant Mouse FABP1/L-FABP Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 9467-CL
Key Product Details
Product Specifications
Source
Met1-Ile127
Purity
Endotoxin Level
N-terminal Sequence Analysis
Predicted Molecular Mass
SDS-PAGE
Activity
Formulation, Preparation and Storage
9467-CL
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution |
Reconstitute at 250 μg/mL in PBS.
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Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Background: FABP1/L-FABP
Fatty acid binding proteins (FABP) are small cytoplasmic lipid binding proteins that are expressed in a tissue specific manner and are involved in intracellular lipid transport. All FABPs bind free fatty acids, cholesterol, and retinoids, which differ in their selectivity, affinity and binding mechanism (1). Circulating FABP levels are used as indicators of tissue damage. Some FABP polymorphisms have been associated with disorders of lipid metabolism and the development of atherosclerosis (2). FABPs are structurally conserved, consisting of a water-filled, ligand-binding pocket surrounded by ten anti-parallel beta-barrel structures, capped by an N-terminal helix-turn-helix motif. The helical N-terminus is involved in the regulation of FA transfer from membranes (3).FABP1, also known as liver FABP (L-FABP) is highly expressed in the liver, intestine, kidney and lung (1). FABP1 binds free fatty acids and their co-enzyme A derivatives. FABP1 is unique among other members in FABP family, attributed to its ability to bind multiple ligands at once. It has a larger solvent-accessible core in comparison to other FABPs, and this allows for more diverse binding to substrates (1). Mouse FABP1 is 127 amino acids (aa) in length. It is a two beta-sheet molecule that contains an acetylated initiating methionine. Full-length mouse FABP1 shares 94% and 84% aa identity with rat and human FABP1, respectively (4).
References
- Smathers, R. et al. (2011) Hum. Genomics. 5(3):170.
- Furuhashi, M. et al. (2008) Nat. Rev. Drug Discov. 7(6):489.
- Storch, J. et al. (2010) J. Biol. Chem. 285(43):32679.
- Martin, G. et al. (2013) Biochemistry 52(51):9347.
Long Name
Alternate Names
Gene Symbol
UniProt
Additional FABP1/L-FABP Products
Product Documents for Recombinant Mouse FABP1/L-FABP Protein, CF
Product Specific Notices for Recombinant Mouse FABP1/L-FABP Protein, CF
For research use only