Recombinant Mouse FGFR4 Fc Chimera Protein, CF
R&D Systems, part of Bio-Techne | Catalog # 2265-FR
Key Product Details
Source
NS0
Accession #
Structure / Form
Disulfide-linked homodimer
Conjugate
Unconjugated
Applications
Bioactivity
Product Specifications
Source
Mouse myeloma cell line, NS0-derived mouse FGF R4 protein
Mouse FGF R4 (Leu19-Asp366) Accession # Q03142 |
IEGRMDP | Mouse IgG2A (Glu98-Lys330) |
N-terminus | C-terminus |
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
N-terminal Sequence Analysis
Leu19
Predicted Molecular Mass
66 kDa (monomer)
SDS-PAGE
90-100 kDa, reducing conditions
Activity
Measured by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblast cells.
The ED50 for this effect is typically 7-35 ng/mL.
The ED50 for this effect is typically 7-35 ng/mL.
Formulation, Preparation and Storage
2265-FR
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution |
Reconstitute at 100 μg/mL in PBS.
|
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Background: FGFR4
References
- Haugsten, E.M. et al. (2010) Mol. Cancer Res. 8:1439.
- Stark, K.L. et al. (1991) Development 113:641.
- van Heumen, W.R.A. et al. (1999) IUBMB Life 48:73.
- Kwiatkowski, B.A. et al. (2008) J. Cell Physiol. 215:803.
- Korhonen, J. et al. (1992) Int. J. Dev. Biol. 36:323.
- Marics, I. et al. (2002) Development 129:4559.
- Luo, Y. et al. (2010) J. Biol. Chem. 285:30069.
- Partanen, J. et al. (1991) EMBO J. 10:1347.
- Saxena, K. et al. (2010) J. Biol. Chem. 285:26628.
- Shin, D.J. and T.F. Osborne (2009) J. Biol. Chem. 284:11110.
- Wu, X. et al. (2010) J. Biol. Chem. 285:5165.
- Nakamura, M. et al. (2011) J. Biol. Chem. 286:26418.
- Huang, X. et al. (2007) Diabetes 56:2501.
- Sugiyama, N. et al. (2010) Proc. Natl. Acad. Sci. 107:15786.
- Bange, J. et al. (2002) Cancer Res. 62:840.
Long Name
Fibroblast Growth Factor Receptor 4
Alternate Names
CD334, FGF R4
Gene Symbol
FGFR4
UniProt
Additional FGFR4 Products
Product Documents for Recombinant Mouse FGFR4 Fc Chimera Protein, CF
Product Specific Notices for Recombinant Mouse FGFR4 Fc Chimera Protein, CF
For research use only
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