Recombinant Human TRAILR2/TNFRSF10B Protein
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-35030
Key Product Details
Product Specifications
Description
A single non-glycosylated polypeptide chain containing 132 amino acids corresponding to TRAILR2/TNFRSF10B Source: E. coli
Uniprot ID: O14763
Amino Acid Sequence: ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES
Purity
> 97 % pure by SDS-PAGE and HPLC
Endotoxin Level
Less than 1 EU/ug of TRAILR2/TNFRSF10B as determined by LAL method.
Predicted Molecular Mass
14.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Activity
TRAIL-R2 protein is fully biologically active when compared to standard. rHusTRAIL-R2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of rHusTRAIL-R2, TRAIL-induced TNF is suppressed.
Protein / Peptide Type
Recombinant Protein
Scientific Data Images for Recombinant Human TRAILR2/TNFRSF10B Protein
![SDS-PAGE: Recombinant Human TRAILR2/TNFRSF10B Protein [NBP2-35030]](https://resources.bio-techne.com/images/products/Human-TRAIL-R2-TNFRSF10B-Protein-SDS-Page-NBP2-35030-img0001.jpg "SDS-PAGE: Recombinant Human TRAILR2/TNFRSF10B Protein [NBP2-35030]")
SDS-PAGE: Recombinant Human TRAILR2/TNFRSF10B Protein [NBP2-35030]
SDS-Page: Human TRAIL R2/TNFRSF10B Protein [NBP2-35030]Formulation, Preparation and Storage
NBP2-35030
| Formulation | Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4. |
| Preservative | No Preservative |
| Concentration | Lyoph |
| Reconstitution | Recommended to centrifuge prior to opening. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0mg/mL. Apportion stock solutions into working aliquots and store at <-20C. |
| Format | Carrier-Free |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at -20 to -70C as supplied. After reconstitution, store at 2 to 8C for 1 month and at -20 to -70C for long term storage. Avoid repeated freeze-thaw cycles. |
Background: TRAIL R2/TNFRSF10B
Long Name
TRAIL Receptor 2
Alternate Names
CD262, DR5, TNFRSF10B, TRAILR2, sTRAILR2, sTRAILR2/TNFRSF10B, TRAILR2/TNFRSF10B
Gene Symbol
TNFRSF10B
UniProt
Additional TRAIL R2/TNFRSF10B Products
Product Documents for Recombinant Human TRAILR2/TNFRSF10B Protein
Product Specific Notices for Recombinant Human TRAILR2/TNFRSF10B Protein
This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
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