10-Cl-BBQ

Name: 10-Cl-BBQ
Brand: Tocris Bioscience
SKU: 6321

Tocris Bioscience, part of Bio-Techne | Catalog # 6321

Citations (1)

COA / SDS

Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable

Key Product Details

Chemical Name:	10-Chloro-7H-benzimidazo[2,1-a]benz[de]isoquinolin-7-one
Purity:	≥97%

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Technical Data
Citations

Biological Activity for 10-Cl-BBQ

10-Cl-BBQ is a potent aryl hydrocarbon receptor (AhR) agonist, discovered as a screening hit (IC₅₀ = 2.6 nM). Directly binds CD4⁺ T cells to induce AhR-dependent Tregs. Suppresses IL-17 production and prevents insulitis in NOD mice. In vivo half llife ~ 2 hours, orally bioavailable.

Technical Data for 10-Cl-BBQ

Formula	C₁₈H₉ClN₂O
Storage	Store at +4°C
Purity	≥97%
CAS Number	23982-76-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 10-Cl-BBQ

Solubility

Soluble Soluble to 1 mM in DMSO with gentle warming

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References for 10-Cl-BBQ

References are publications that support the biological activity of the product.

Punj et al. Benzimidazoisoquinolines: a new class of rapidly metabolized aryl hydrocarbon receptor (AhR) ligands that induce AhR-dependent Tregs and prevent murine graft-versus-host disease. PLoS One, 2014;9:e88726 PMID: 24586378
Ehrlich et al. Activation of the aryl hydrocarbon receptor by 10-Cl-BBQ prevents insulitis and effector T cell development independently of Foxp3+ regulatory T Cells in nonobese diabetic mice. J.Immunol., 2016;196:264 PMID: 26573835

10-Cl-BBQ

Tocris Bioscience, part of Bio-Techne | Catalog # 6321

Key Product Details

Biological Activity for 10-Cl-BBQ

Technical Data for 10-Cl-BBQ

Solubility for 10-Cl-BBQ

Dilution Calculator

Reconstitution Calculator

References for 10-Cl-BBQ

Product Documents for 10-Cl-BBQ

COA

Certificate of Analysis

SDS

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