10-DEBC hydrochloride

Name: 10-DEBC hydrochloride
Brand: Tocris Bioscience
SKU: 2558

Tocris Bioscience, part of Bio-Techne | Catalog # 2558

(1)

Citations (8)

COA / SDS

Selective Akt/PKB inhibitor

Key Product Details

Chemical Name:	10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Purity:	≥99%
Molecular Weight:	381.34 kDa

View Full Technical Details for 10-DEBC hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for 10-DEBC hydrochloride

10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC₅₀ ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Technical Data for 10-DEBC hydrochloride

M. Wt	381.34 kDa
Formula	C₂₀H₂₅N₂OCl.HCl
Storage	Desiccate at +4°C
Purity	≥99%
CAS Number	925681-41-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 10-DEBC hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for 10-DEBC hydrochloride

References are publications that support the biological activity of the product.

Thimmaiah et al. Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. J.Med.Chem., 1992;35:3358 PMID: 1527786
Thimmaiah et al. Identification of N¹⁰-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J.Biol.Chem., 2005;36:31924