10-DEBC hydrochloride

Name: 10-DEBC hydrochloride
Brand: Tocris Bioscience
SKU: 2558
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2558

(1)

Citations (8)

COA / SDS

Selective Akt/PKB inhibitor

Key Product Details

Description:	Selective Akt/PKB inhibitor
Alternative Names:	Akt Inhibitor X
Chemical Name:	10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	381.34

View Full Technical Details for 10-DEBC hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for 10-DEBC hydrochloride

10-DEBC hydrochloride is a selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC₅₀ ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Compound Libraries for 10-DEBC hydrochloride

10-DEBC hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 10-DEBC hydrochloride

M. Wt	381.34
Formula	C₂₀H₂₅N₂OCl.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	925681-41-0
PubChem ID	16760284
InChi Key	SVKSJUIYYCQZEC-UHFFFAOYSA-N
Smiles	Cl.CCN(CC)CCCCN1C2=CC=CC=C2OC2=C1C=C(Cl)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 10-DEBC hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	38.13	100
	DMSO	38.13	100

Preparing Stock Solutions for 10-DEBC hydrochloride

The following data is based on the product molecular weight 381.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.11 mL	26.22 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for 10-DEBC hydrochloride

References are publications that support the biological activity of the product.

Thimmaiah Identification of N¹⁰-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J.Biol.Chem.
Thimmaiah Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. J.Med.Chem. 1992 PMID: 1527786