142D6

Name: 142D6
Brand: Tocris Bioscience
SKU: 8018

Tocris Bioscience, part of Bio-Techne | Catalog # 8018

COA / SDS

Potent Lys-covalent pan-IAP inhibitor

Key Product Details

Description:	Potent Lys-covalent pan-IAP inhibitor
Chemical Name:	(R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate
Purity:	≥95% (HPLC)
Molecular Weight:	552.66

View Full Technical Details for 142D6

Technical Data
Citations

Biological Activity for 142D6

142D6 is a potent pan-IAP inhibitor (IC₅₀ values are 21, 21 and 43 nM for cIAP1, cIAP2 and XIAP respectively). 142D6 covalently targets Lys residues in the BIR3 domain of the inhibitor of the apoptosis protein (IAP) family. In vitro, 142D6 reduces viability of cultured breast cancer MDA-MB-231 cells (EC₅₀values are 44 and 61 nM in cell viability and apoptosis assays, respectively). 142D6 is chemically stable in buffer and plasma and is orally bioavailable.

Licensing Information

Sold under patent license from The Regents of the University of California

Technical Data for 142D6

M. Wt	552.66
Formula	C₂₆H₃₇FN₄O₆S
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2410953-19-2
InChi Key	YVERFLKIJOIKPE-HXGJMTJLSA-N
Smiles	O=C([C@H]1N(CCC1)C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)N[C@H]3C4=CC=CC(OS(F)(=O)=O)=C4CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 142D6

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	55.27	100

Preparing Stock Solutions for 142D6

The following data is based on the product molecular weight 552.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.81 mL	9.05 mL	18.09 mL
5 mM	0.36 mL	1.81 mL	3.62 mL
10 mM	0.18 mL	0.90 mL	1.81 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for 142D6

References are publications that support the biological activity of the product.

Udompholkul Characterization of a potent and orally bioavailable Lys-covalent inhibitor of apoptosis protein (IAP) antagonist. J.Med.Chem. 2023 PMID: 37262387
Baggio Aryl-fluorosulfate-based lysine covalent pan-inhibitors of apoptosis protein (IAP) antagonists with cellular efficacy. J.Med.Chem. 2019 PMID: 31550155