16,16-Dimethyl Prostaglandin E2

Name: 16,16-Dimethyl Prostaglandin E2
Brand: Tocris Bioscience
SKU: 4027

Tocris Bioscience, part of Bio-Techne | Catalog # 4027

Citations (8)

COA / SDS

Synthetic prostaglandin E2 (Cat. No. 2296) derivative; regulates HSC development

Key Product Details

Chemical Name:	(5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid
Purity:	≥95%
Molecular Weight:	380.52 kDa

View Full Technical Details for 16,16-Dimethyl Prostaglandin E2

Technical Data
Citations

Biological Activity for 16,16-Dimethyl Prostaglandin E2

16,16-Dimethyl Prostaglandin E2 is a synthetic derivative of prostaglandin E₂ (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data for 16,16-Dimethyl Prostaglandin E2

M. Wt	380.52 kDa
Formula	C₂₂H₃₆O₅
Storage	Store at -80°C
Purity	≥95%
CAS Number	39746-25-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 16,16-Dimethyl Prostaglandin E2

Solubility

Soluble Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)

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References for 16,16-Dimethyl Prostaglandin E2

References are publications that support the biological activity of the product.

Jansen S, Holman R, Hedemann I, Frankes E, Elzinga C, Timens W, Gosens R, de Bont E, Schmidt M Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via beta-catenin stabilization. J Cell Mol Med, 2015;19(1):210-26. 2015 PMID: 25266063
Heffner et al. Prostaglandin E₂ increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells. Mol.Ther, 2018;26:320 PMID: 29102562
North et al. Prostaglandin E₂ regulates vertebrate haematopoietic stem cell homeostasis. Nature., 2007;447:1007 PMID: 17581586
Lord et al. Prostaglandin E₂: making more of your marrow. Cell Cycle., 2007;6:3054 PMID: 18075310
Goessling et al. Genetic interaction of PGE₂ and wnt signaling regulates developmental specification of stem cells and regeneration. Cell., 2009;136:1136 PMID: 19303855