27-Hydroxycholesterol

Name: 27-Hydroxycholesterol
Brand: Tocris Bioscience
SKU: 3907

Tocris Bioscience, part of Bio-Techne | Catalog # 3907

Citations (4)

COA / SDS

LXR agonist; also ER partial agonist

Key Product Details

Chemical Name:	(3β,25R)-Cholest-5-ene-3,26-diol
Purity:	≥95%

View Full Technical Details for 27-Hydroxycholesterol

Technical Data
Citations

Biological Activity for 27-Hydroxycholesterol

27-Hydroxycholesterol is a liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

Technical Data for 27-Hydroxycholesterol

Formula	C₂₇H₄₆O₂
Storage	Store at -20°C
Purity	≥95%
CAS Number	20380-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 27-Hydroxycholesterol

Solubility

Soluble Soluble to 20 mM in ethanol

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References for 27-Hydroxycholesterol

References are publications that support the biological activity of the product.

Fu et al. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem., 2001;276:38378 PMID: 11504730
DuSell et al. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol., 2008;22:65 PMID: 17872378
Rantham Prabhakara et al. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem., 2008;107:1722 PMID: 19014385

27-Hydroxycholesterol

Tocris Bioscience, part of Bio-Techne | Catalog # 3907

Key Product Details

Biological Activity for 27-Hydroxycholesterol

Technical Data for 27-Hydroxycholesterol

Solubility for 27-Hydroxycholesterol

Dilution Calculator

Reconstitution Calculator

References for 27-Hydroxycholesterol

Product Documents for 27-Hydroxycholesterol

COA

Certificate of Analysis

SDS

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