3',2'-cGAMP sodium salt

Name: 3',2'-cGAMP sodium salt
Brand: Tocris Bioscience
SKU: 7718

Tocris Bioscience, part of Bio-Techne | Catalog # 7718

COA / SDS

Induces expression of STING and STING-related genes; antiviral

Key Product Details

Description:	Induces expression of STING and STING-related genes; antiviral
Chemical Name:	3',2'-Cyclic guanosine monophosphate-adenosine monophosphate sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	718.38

View Full Technical Details for 3',2'-cGAMP sodium salt

Technical Data
Citations

Biological Activity for 3',2'-cGAMP sodium salt

3',2'-cGAMP sodium salt is a second messenger in the antiviral immune response in Drosophila melanogaster and in bacteria. 3',2'-cGAMP is selective for Drosophila stimulator of interferon genes (dSTING); induces expression of STING and STING-related genes. After injection of drosophila C virus dsRNA into Drosophila, 3',2'-cGAMP activates STING-dependent antiviral immunity in vivo, reduces viral RNA load and increases survival. In bacteria 3',2'-cGAMP activates DNA degradation of AsCap5 and LlCap5.

Technical Data for 3',2'-cGAMP sodium salt

M. Wt	718.38
Formula	C₂₀H₂₂N₁₀Na₂O₁₃P₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
InChi Key	ROQCYAKTZSZNCA-DQNSRKNCSA-L
Smiles	O[C@H]1[C@@]2([C@@]([H])(O[C@@]1(COP([O-])(O[C@@]3([C@@]([H])(COP([O-])(O2)=O)O[C@]([H])([C@@H]3O)N4C5=C(N=C4)C(N=C(N)N5)=O)[H])=O)[H])N6C7=NC=NC(N)=C7N=C6)[H].[Na+].[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3',2'-cGAMP sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	7.18	10

Preparing Stock Solutions for 3',2'-cGAMP sodium salt

The following data is based on the product molecular weight 718.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.92 mL	69.60 mL	139.20 mL
0.5 mM	2.78 mL	13.92 mL	27.84 mL
1 mM	1.39 mL	6.96 mL	13.92 mL
5 mM	0.28 mL	1.39 mL	2.78 mL

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References for 3',2'-cGAMP sodium salt

References are publications that support the biological activity of the product.

Fatma Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger. Nat.Commun. 2021 PMID: 34737303
Slavik cGAS-like receptors sense RNA and control 3',2'-cGAMP signalling in Drosophila. Nature 2021 PMID: 34261127