3-Bromopyruvate

Name: 3-Bromopyruvate
Brand: Tocris Bioscience
SKU: 7512

Tocris Bioscience, part of Bio-Techne | Catalog # 7512

COA / SDS

MCT1 inhibitor; also inhibits hexokinase II

Key Product Details

Description:	MCT1 inhibitor; also inhibits hexokinase II
Chemical Name:	3-Bromo-2-oxopropanoic acid
Molecular Weight:	166.96

View Full Technical Details for 3-Bromopyruvate

Technical Data
Citations

Biological Activity for 3-Bromopyruvate

3-Bromopyruvate is a monocarboxylate transporter (MCT1) inhibitor (IC₅₀ = 14.7 μM, 24.2 μM and 28.6 μM in SiHa, UM-UC-3, and HCT-116 human cancer cell lines, respectively). 3-Bromopyruvate shows antitumor activity in vitro and in vivo. 3-Bromopyruvate is also an inhibitor of hexokinase II, and decreases apoptosis in dopaminergic neurons in Parkinson's disease models in vitro and in vivo.

Technical Data for 3-Bromopyruvate

M. Wt	166.96
Formula	C₃H₃BrO₃
Storage	Store at -20°C
CAS Number	1113-59-3
PubChem ID	70684
InChi Key	PRRZDZJYSJLDBS-UHFFFAOYSA-N
Smiles	O=C(O)C(=O)CBr

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 3-Bromopyruvate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	16.7	100

Preparing Stock Solutions for 3-Bromopyruvate

The following data is based on the product molecular weight 166.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.99 mL	29.95 mL	59.89 mL
5 mM	1.20 mL	5.99 mL	11.98 mL
10 mM	0.60 mL	2.99 mL	5.99 mL
50 mM	0.12 mL	0.60 mL	1.20 mL

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Reconstitution Calculator

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References for 3-Bromopyruvate

References are publications that support the biological activity of the product.

Li Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiol. Dis. 2022 PMID: 34973450
Vander Linden Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell Rep. 2021 PMID: 34077729