5-Iodotubercidin

Name: 5-Iodotubercidin
Brand: Tocris Bioscience
SKU: 1745

Tocris Bioscience, part of Bio-Techne | Catalog # 1745

Citations (24)

COA / SDS

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Key Product Details

Chemical Name:	5-Iodo-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity:	≥97%
Molecular Weight:	392.15 kDa

View Full Technical Details for 5-Iodotubercidin

Technical Data
Citations

Biological Activity for 5-Iodotubercidin

5-Iodotubercidin is a potent adenosine kinase inhibitor (IC₅₀ = 26 nM). Also nucleoside transporter inhibitor (IC₅₀ values are < 25 nM, 7 μM and 15 μM for inhibition of [³H]adenosine, [³H]uridine and [³H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC₅₀ values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Technical Data for 5-Iodotubercidin

M. Wt	392.15 kDa
Formula	C₁₁H₁₃IN₄O₄
Storage	Store at -20°C
Purity	≥97%
CAS Number	24386-93-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 5-Iodotubercidin

Solubility

Soluble Soluble to 50 mM in DMSO

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References for 5-Iodotubercidin

References are publications that support the biological activity of the product.

Pisanti S, Picardi P, Ciaglia E, Margarucci L, Ronca R, Giacomini A, Malfitano A, Casapullo A, Laezza C, Gazzerro P, Bifulco M Antiangiogenic effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, mediated by AMPK activation. FASEB J, 2014;28(3):1132-44. 2014 PMID: 24265487
Williams-Karnesky et al. Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J.Clin.Invest., 2013;123:3552 PMID: 23863710
Massillon et al. Identification of the glycogenic compound 5-iodotubercidin as a general protein kinase inhibitor. Biochem.J., 1994;299:123 PMID: 8166629
Parkinson and Geiger Effects of iodotubercidin on adenosine kinase activity and nucleoside transport in DDT₁ MF-2 smooth muscle cells. J.Pharmacol.Exp.Ther., 1996;277:1397 PMID: 8667202
Ugarkar et al. Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues. J.Med.Chem., 2000;43:2883 PMID: 10956196