A 1070722

Name: A 1070722
Brand: Tocris Bioscience
SKU: 4431

Tocris Bioscience, part of Bio-Techne | Catalog # 4431

Citations (5)

COA / SDS

Highly potent, selective GSK-3 inhibitor

Key Product Details

Description:	Highly potent, selective GSK-3 inhibitor
Chemical Name:	1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Purity:	≥99% (HPLC)
Molecular Weight:	362.31

View Full Technical Details for A 1070722

Technical Data
Citations

Biological Activity for A 1070722

A 1070722 is a potent glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.

Compound Libraries for A 1070722

A 1070722 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 1070722

M. Wt	362.31
Formula	C₁₇H₁₃F₃N₄O₂
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1384424-80-9
PubChem ID	49830684
InChi Key	VQPBIJGXSXEOCU-UHFFFAOYSA-N
Smiles	O=C(NC3=NC(C(F)(F)F)=CC=C3)NC2=CC=NC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 1070722

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.23	100

Preparing Stock Solutions for A 1070722

The following data is based on the product molecular weight 362.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.80 mL	27.60 mL
5 mM	0.55 mL	2.76 mL	5.52 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for A 1070722

References are publications that support the biological activity of the product.

Bakker A-1070722, a potent, selective, and centrally active glycogen synthase kinase-3 (GSK-3) inhibitor for the treatment of psychiatric and neurodegenerative disorders. Society for Neuroscience (Abstract)