A 1120

Name: A 1120
Brand: Tocris Bioscience
SKU: 3793

Tocris Bioscience, part of Bio-Techne | Catalog # 3793

Citations (1)

COA / SDS

High affinity retinol-binding protein 4 (RBP4) ligand

Key Product Details

Description:	High affinity retinol-binding protein 4 (RBP4) ligand
Chemical Name:	2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	392.37

View Full Technical Details for A 1120

Technical Data
Citations

Biological Activity for A 1120

A 1120 is a high affinity retinol-binding protein 4 (RBP4) ligand (K_i = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.

Compound Libraries for A 1120

A 1120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A 1120

M. Wt	392.37
Formula	C₂₀H₁₉F₃N₂O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1152782-19-8
PubChem ID	25138295
InChi Key	MEAQCLPMSVEOQF-UHFFFAOYSA-N
Smiles	O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 1120

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.24	100
	ethanol	9.81	25

Preparing Stock Solutions for A 1120

The following data is based on the product molecular weight 392.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.49 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for A 1120

References are publications that support the biological activity of the product.

Motani Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 2009 PMID: 19147488
Manolescu All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice. J.Nutr. 2009 PMID: 20032483