A 196

Name: A 196
Brand: Tocris Bioscience
SKU: 6167

Tocris Bioscience, part of Bio-Techne | Catalog # 6167

Citations (2)

COA / SDS

Potent and selective SUV420H1/H2 inhibitor

Key Product Details

Chemical Name:	6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine
Purity:	≥98%

View Full Technical Details for A 196

Technical Data
Citations

Biological Activity for A 196

A 196 is a potent and selective SUV420H1/H2 inhibitor (IC₅₀ values are 25 and 144 nM respectively) that exhibits 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. A 196 inhibits the di- and tri-methylation of H4K20me in multiple cell lines (IC₅₀ < 1 μM).

To request the negative control for A 196, please fill out the SGC 2043 request form on the SGC website.

Technical Data for A 196

Formula	C₁₈H₁₆Cl₂N₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	1982372-88-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 196

Solubility

Soluble Soluble to 20 mM in DMSO

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References for A 196

References are publications that support the biological activity of the product.

Scheer et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun., 2019;10:19 PMID: 30604761
Bromberg et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat.Chem.Biol., 2017;13:317 PMID: 28114273
Brustel et al. Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. EMBO J, 2017;36:2726 PMID: 28778956

A 196

Tocris Bioscience, part of Bio-Techne | Catalog # 6167

Key Product Details

Biological Activity for A 196

Technical Data for A 196

Solubility for A 196

Dilution Calculator

Reconstitution Calculator

References for A 196

Product Documents for A 196

COA

Certificate of Analysis

SDS

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