A 33

Name: A 33
Brand: Tocris Bioscience
SKU: 6313

Tocris Bioscience, part of Bio-Techne | Catalog # 6313

Citations (3)

COA / SDS

Potent and selective PDE4B inhibitor

Key Product Details

Chemical Name:	2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
Purity:	≥98%

View Full Technical Details for A 33

Technical Data
Citations

Biological Activity for A 33

A 33 is a potent and selective PDE4B inhibitor (IC₅₀ = 15 nM); exhibits >100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. Also exhibits antidepressant-like effects. Orally bioavailable.

Technical Data for A 33

Formula	C₁₉H₁₈ClN₃O₂S
Storage	Store at -20°C
Purity	≥98%
CAS Number	915082-52-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 33

Solubility

Soluble Soluble to 100 mM in DMSO

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References for A 33

References are publications that support the biological activity of the product.

Naganuma et al. Discovery of selective PDE4B inhibitors. Bioorg.Med.Chem.Lett., 2009;19:3174 PMID: 19447034
Zhang et al. Comparison of the pharmacological profiles of selective PDE4B and PDE4D inhibitors in the central nervous system. Sci.Rep., 2017;7:40115 PMID: 28054669
Wilson et al. Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury. PLoS One, 2017;12:e0178013 PMID: 28542295

A 33

Tocris Bioscience, part of Bio-Techne | Catalog # 6313

Key Product Details

Biological Activity for A 33

Technical Data for A 33

Solubility for A 33

Dilution Calculator

Reconstitution Calculator

References for A 33

Product Documents for A 33

COA

Certificate of Analysis

SDS

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