A 366

Name: A 366
Brand: Tocris Bioscience
SKU: 5163

Tocris Bioscience, part of Bio-Techne | Catalog # 5163

Citations (4)

COA / SDS

Potent and selective G9a/GLP inhibitor

Key Product Details

Chemical Name:	5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Purity:	≥98%

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Technical Data
Citations

Biological Activity for A 366

A 366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). Exhibits >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. Decreases levels of lysine 9 dimethylation on histone H3 (H3K9Me2) in PC3 cells.

Technical Data for A 366

Formula	C₁₉H₂₇N₃O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	1527503-11-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 366

Solubility

Soluble Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

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References for A 366

References are publications that support the biological activity of the product.

Scheer et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun., 2019;10:19 PMID: 30604761
Sweis et al. Discovery and development of potent and selective inhibitors of histone methyltransferase G9a. ACS Med.Chem.Lett., 2014;5:205 PMID: 24900801

A 366

Tocris Bioscience, part of Bio-Techne | Catalog # 5163

Key Product Details

Biological Activity for A 366

Technical Data for A 366

Solubility for A 366

Dilution Calculator

Reconstitution Calculator

References for A 366

Product Documents for A 366

COA

Certificate of Analysis

SDS

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