A 419259 trihydrochloride

Name: A 419259 trihydrochloride
Brand: Tocris Bioscience
SKU: 3914

Tocris Bioscience, part of Bio-Techne | Catalog # 3914

(1)

Citations (9)

COA / SDS

Inhibitor of Src family kinases

Key Product Details

Chemical Name:	7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for A 419259 trihydrochloride

A 419259 trihydrochloride is a potent Hck inhibitor (IC₅₀ = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34⁺. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

Technical Data for A 419259 trihydrochloride

Formula	C₂₉H₃₄N₆O.3HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	1435934-25-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 419259 trihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 20 mM in DMSO

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References for A 419259 trihydrochloride

References are publications that support the biological activity of the product.

Saito et al. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci.Transl.Med., 2013;5 PMID: 23596204
Wilson et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene, 2002;21:8075 PMID: 12444544
Pene-Dumitrescu et al. An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad spectrum Src family kinase inhibitor A-419259. Oncogene, 2008;27:7055 PMID: 18794796

A 419259 trihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3914

Key Product Details

Biological Activity for A 419259 trihydrochloride

Technical Data for A 419259 trihydrochloride

Solubility for A 419259 trihydrochloride

Dilution Calculator

Reconstitution Calculator

References for A 419259 trihydrochloride

Product Documents for A 419259 trihydrochloride

COA

Certificate of Analysis

SDS

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