A 77-01

Name: A 77-01
Brand: Tocris Bioscience
SKU: 6712

Tocris Bioscience, part of Bio-Techne | Catalog # 6712

Citations (1)

COA / SDS

Potent inhibitor of TGF-βRI

Key Product Details

Chemical Name:	4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline
Purity:	≥98%

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Technical Data
Citations

Biological Activity for A 77-01

A 77-01 is a potent TGF-βRI (ALK-5) inhibitor (IC₅₀ = 34 nM). Inhibits TGF-β transcriptional activation. Inhibits TGF-β-induced proliferation of lung epithelial cells and SMAD phosphorylation. Inhibits TGF-β-induced epithelial-to-mesenchymal transition (EMT). Also inhibitor of p38 MAPK. Likely active metabolite of A 83-01 (Cat. No. 2939).

Technical Data for A 77-01

Formula	C₁₈H₁₄N₄
Storage	Store at +4°C
Purity	≥98%
CAS Number	607737-87-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 77-01

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl

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References for A 77-01

References are publications that support the biological activity of the product.

Tojo et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer Sci., 2005;96:791 PMID: 16271073
Sawyer et al. Synthesis and activity of new aryl- and heteroaryl-substituted pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain. J.Med.Chem., 2003;46:3953 PMID: 12954047

A 77-01

Tocris Bioscience, part of Bio-Techne | Catalog # 6712

Key Product Details

Biological Activity for A 77-01

Technical Data for A 77-01

Solubility for A 77-01

Dilution Calculator

Reconstitution Calculator

References for A 77-01

Product Documents for A 77-01

COA

Certificate of Analysis

SDS

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