A 939572

Name: A 939572
Brand: Tocris Bioscience
SKU: 4845

Tocris Bioscience, part of Bio-Techne | Catalog # 4845

Citations (10)

COA / SDS

Potent SCD-1 inhibitor

Key Product Details

Description:	Potent SCD-1 inhibitor
Chemical Name:	4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Purity:	≥99% (HPLC)
Molecular Weight:	387.86

View Full Technical Details for A 939572

Technical Data
Citations

Biological Activity for A 939572

A 939572 is a potent stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC₅₀ = 0.4 nM). Selective for SCD1 over a range of kinases and hERG channels. Inhibits proliferation of squamous cell carcinoma FaDu cells in vitro. Also induces cell death of undifferentiated human embryonic stem cells (ESCs). Orally bioavailable.

Compound Libraries for A 939572

A 939572 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for A 939572

M. Wt	387.86
Formula	C₂₀H₂₂ClN₃O₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1032229-33-6
PubChem ID	24905400
InChi Key	DPYTYQFYDLYWHZ-UHFFFAOYSA-N
Smiles	O=C(NC3=CC(C(NC)=O)=CC=C3)N1CCC(OC2=C(Cl)C=CC=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 939572

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	38.79	100

Preparing Stock Solutions for A 939572

The following data is based on the product molecular weight 387.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.58 mL	12.89 mL	25.78 mL
5 mM	0.52 mL	2.58 mL	5.16 mL
10 mM	0.26 mL	1.29 mL	2.58 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for A 939572

References are publications that support the biological activity of the product.

Xin Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors. Bioorg.Med.Chem.Lett. 2008 PMID: 18632269
Ben-David Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 2013 PMID: 23318055