A 971432

Name: A 971432
Brand: Tocris Bioscience
SKU: 5766

Tocris Bioscience, part of Bio-Techne | Catalog # 5766

Citations (5)

COA / SDS

Potent and selective S1P5 agonist

Key Product Details

Description:	Potent and selective S1P₅ agonist
Chemical Name:	1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	366.24

View Full Technical Details for A 971432

Technical Data
Citations

Biological Activity for A 971432

A 971432 is a potent and selective S1P₅ agonist (EC₅₀ values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P₁, and >1,600-fold selectivity over S1P_2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Technical Data for A 971432

M. Wt	366.24
Formula	C₁₈H₁₇Cl₂NO₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	1240308-45-5
PubChem ID	46872626
InChi Key	WAAWETUDFSIYSD-UHFFFAOYSA-N
Smiles	ClC1=C(Cl)C=C(COC2=CC=C(CN3CC(C(O)=O)C3)C=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A 971432

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	36.62	100
	1eq. HCl	36.62	100

Preparing Stock Solutions for A 971432

The following data is based on the product molecular weight 366.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.65 mL	27.30 mL
5 mM	0.55 mL	2.73 mL	5.46 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for A 971432

References are publications that support the biological activity of the product.

Hobson Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P₅) agonist for the potential treatment of neurodegenerative disorders. J.Med.Chem. 2015 PMID: 26509640