A37

Name: A37
Brand: Tocris Bioscience
SKU: 5802

Tocris Bioscience, part of Bio-Techne | Catalog # 5802

Citations (2)

COA / SDS

ALDH1A1 inhibitor

Key Product Details

Description:	ALDH1A1 inhibitor
Alternative Names:	CM 037
Chemical Name:	Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate
Purity:	≥97% (HPLC)
Molecular Weight:	431.57

View Full Technical Details for A37

Technical Data
Citations

Biological Activity for A37

A37 is an ALDH1A1 inhibitor (IC₅₀ = 4.6 μM; K_i = 300 nM). Exhibits selectivity for ALDH1A1 over eight other ALDH isoforms. Disrupts spheroid formation and reduces cell viability of ovarian cancer cells in vitro.

Compound Libraries for A37

A37 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for A37

M. Wt	431.57
Formula	C₂₁H₂₅N₃O₃S₂
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	896795-60-1
PubChem ID	5049161
InChi Key	SKDRHRAYBYQVNU-UHFFFAOYSA-N
Smiles	O=C1N(CCCN2CCCC2)C(SCC(OCC)=O)=NC3=C1SC4=C3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for A37

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.16	100
	ethanol	43.16	100

Preparing Stock Solutions for A37

The following data is based on the product molecular weight 431.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.17 mL
5 mM	0.46 mL	2.32 mL	4.63 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for A37

References are publications that support the biological activity of the product.

Condello β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids. Oncogene 2015 PMID: 24954508
Morgan and Hurley Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors. J.Med.Chem 2015 PMID: 25634381

A37