AA 147

Name: AA 147
Brand: Tocris Bioscience
SKU: 6759
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6759

(1)

Citations (9)

COA / SDS

ER proteostasis regulator

Key Product Details

Description:	ER proteostasis regulator
Chemical Name:	N-(2-Hydroxy-5-methylphenyl)benzenepropanamide
Purity:	≥98% (HPLC)
Molecular Weight:	255.31

View Full Technical Details for AA 147

Technical Data
Citations / Reviews (1)

Biological Activity for AA 147

AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC₅₀ = 1.1 μM).

Compound Libraries for AA 147

AA 147 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AA 147

M. Wt	255.31
Formula	C₁₆H₁₇NO₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	393121-74-9
PubChem ID	882909
InChi Key	AWHLTHOHBAGPMY-UHFFFAOYSA-N
Smiles	CC1=CC(NC(CCC2=CC=CC=C2)=O)=C(C=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AA 147

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	25.53	100
	ethanol	25.53	100

Preparing Stock Solutions for AA 147

The following data is based on the product molecular weight 255.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.92 mL	19.58 mL	39.17 mL
5 mM	0.78 mL	3.92 mL	7.83 mL
10 mM	0.39 mL	1.96 mL	3.92 mL
50 mM	0.08 mL	0.39 mL	0.78 mL

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Reconstitution Calculator

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References for AA 147

References are publications that support the biological activity of the product.

Plate Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. Elife 2016 PMID: 27435961