ABP 688

Name: ABP 688
Brand: Tocris Bioscience
SKU: 5229

Tocris Bioscience, part of Bio-Techne | Catalog # 5229

Citations (4)

COA / SDS

High affinity human mGlu5 antagonist

Key Product Details

Description:	High affinity human mGlu₅ antagonist
Chemical Name:	3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
Purity:	≥98% (HPLC)
Molecular Weight:	240.3

View Full Technical Details for ABP 688

Technical Data
Citations

Biological Activity for ABP 688

ABP 688 is a high affinity human mGlu₅ receptor antagonist (K_i = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu₅ receptors (IC₅₀ = 2.3 nM).

Technical Data for ABP 688

M. Wt	240.3
Formula	C₁₅H₁₆N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	924298-51-1
PubChem ID	11481862
InChi Key	CNNZLFXCUQLKOB-BMRADRMJSA-N
Smiles	CC1=CC=CC(C#CC(CCC2)=C/C2=N/OC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABP 688

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.03	100
	1eq. HCl	12.02	50

Preparing Stock Solutions for ABP 688

The following data is based on the product molecular weight 240.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.16 mL	20.81 mL	41.61 mL
5 mM	0.83 mL	4.16 mL	8.32 mL
10 mM	0.42 mL	2.08 mL	4.16 mL
50 mM	0.08 mL	0.42 mL	0.83 mL

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References for ABP 688

References are publications that support the biological activity of the product.

Hintermann ABP688, a novel selective and high affinity ligand for the labeling of mGlu₅ receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 2007 PMID: 17110115