AC 1903

Name: AC 1903
Brand: Tocris Bioscience
SKU: 6766

Tocris Bioscience, part of Bio-Techne | Catalog # 6766

Citations (2)

COA / SDS

Selective TRPC5 inhibitor

Key Product Details

Description:	Selective TRPC5 inhibitor
Chemical Name:	N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	303.36

View Full Technical Details for AC 1903

Technical Data
Citations

Biological Activity for AC 1903

AC 1903 is a selective TRPC5 blocker (IC₅₀ = 4.0 - 13.6 μM). Also displays weak inhibition at TRPC4 (IC₅₀ >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Compound Libraries for AC 1903

AC 1903 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AC 1903

M. Wt	303.36
Formula	C₁₉H₁₇N₃O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	831234-13-0
PubChem ID	667146
InChi Key	OECUWHDVQIITIS-UHFFFAOYSA-N
Smiles	C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 1903

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	15.17	50

Preparing Stock Solutions for AC 1903

The following data is based on the product molecular weight 303.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.59 mL	32.96 mL	65.93 mL
2.5 mM	1.32 mL	6.59 mL	13.19 mL
5 mM	0.66 mL	3.30 mL	6.59 mL
25 mM	0.13 mL	0.66 mL	1.32 mL

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References for AC 1903

References are publications that support the biological activity of the product.

Sharma Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg.Med.Chem.Lett. 2019 PMID: 30538066
Zhou A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 2017 PMID: 29217578
Minard Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease. Cells 2018 PMID: 29865154
Chung TRP'ing up chronic kidney disease. Science 2017 PMID: 29217557