AC 55541

Name: AC 55541
Brand: Tocris Bioscience
SKU: 3369

Tocris Bioscience, part of Bio-Techne | Catalog # 3369

Citations (12)

COA / SDS

Potent and selective PAR2 agonist

Key Product Details

Chemical Name:	(2E)-2-[1-(3-Bromophenyl)ethylidene] α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid hydrazide
Purity:	≥97%
Molecular Weight:	518.36 kDa

View Full Technical Details for AC 55541

Technical Data
Citations

Biological Activity for AC 55541

AC 55541 is a potent and selective protease-activated receptor 2 (PAR₂) agonist (pEC₅₀ = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. Stimulates cell proliferation, PI hydrolysis and Ca²⁺ mobilization in vitro (pEC₅₀ values are 6.7, 5.9 and 6.6 respectively) and exhibits pronociceptive activity in vivo.

Technical Data for AC 55541

M. Wt	518.36 kDa
Formula	C₂₅H₂₀BrN₅O₃
Storage	Store at -20°C
Purity	≥97%
CAS Number	916170-19-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 55541

Solubility

Soluble Soluble to 50 mM in DMSO

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References for AC 55541

References are publications that support the biological activity of the product.

Seitzberg et al. Discovery of potent and selective small-molecule PAR-2 agonists. J.Med.Chem., 2008;51:5490 PMID: 18720984
Gardell et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J.Pharmacol.Exp.Ther., 2008;327:799 PMID: 18768780