Ac-FLTD-CMK

Name: Ac-FLTD-CMK
Brand: Tocris Bioscience
SKU: 7242

Tocris Bioscience, part of Bio-Techne | Catalog # 7242

COA / SDS

Potent and selective inhibitor of caspases 1, 5 and 4

Key Product Details

Description:	Potent and selective inhibitor of caspases 1, 5 and 4
Purity:	≥95% (HPLC)
Molecular Weight:	569.05

View Full Technical Details for Ac-FLTD-CMK

Technical Data
Citations

Biological Activity for Ac-FLTD-CMK

Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC₅₀ values = 46.7 nM, 0.33 μM, 1.49 μM, respectively), and inhibits murine caspase-11 at 10 μM. Ac-FLTD-CMK inhibits cleavage of gasdermin D by caspases, suppresses pyroptosis and reduces IL-1β release in macrophages.

Technical Data for Ac-FLTD-CMK

M. Wt	569.05
Formula	C₂₆H₃₇ClN₄O₈
Single Letter Sequence	FLTD (Modifications: Phe-1 = Ac-Phe, Asp-4 = Asp-CMK)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2376255-48-8
PubChem ID	155906572
InChi Key	UCWNTWGHVCSMJP-WPUDHWPRSA-N
Smiles	O=C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)[C@H](CC1=CC=CC=C1)NC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ac-FLTD-CMK

Solubility

Soluble to 1mg/ml in DMSO

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References for Ac-FLTD-CMK

References are publications that support the biological activity of the product.

Yang Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc.Natl.Acad.Sci.U.S.A. 2018 PMID: 29891674