Acarbose

Name: Acarbose
Brand: Tocris Bioscience
SKU: 2673

Tocris Bioscience, part of Bio-Techne | Catalog # 2673

Citations (5)

COA / SDS

Glucosidase α inhibitor (intestinal)

Key Product Details

Description:	Glucosidase α inhibitor (intestinal)
Alternative Names:	Bay-g 5421
Chemical Name:	O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-Glucose
Molecular Weight:	645.25

View Full Technical Details for Acarbose

Technical Data
Citations

Biological Activity for Acarbose

Acarbose is an inhibitor of intestinal α-glucosidase (IC₅₀ = 11 nM). Antidiabetic; inhibits the hydrolysis of complex carbohydrates.

Compound Libraries for Acarbose

Acarbose is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Acarbose

M. Wt	645.25
Formula	C₂₅H₄₃NO₁₈
Storage	Desiccate at RT
CAS Number	56180-94-0
PubChem ID	444254
InChi Key	XUFXOAAUWZOOIT-SXARVLRPSA-N
Smiles	C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Acarbose

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	64.52	100
	DMSO	64.52	100

Preparing Stock Solutions for Acarbose

The following data is based on the product molecular weight 645.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.55 mL	7.75 mL	15.50 mL
5 mM	0.31 mL	1.55 mL	3.10 mL
10 mM	0.15 mL	0.77 mL	1.55 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

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References for Acarbose

References are publications that support the biological activity of the product.

Balfour and McTavish Acarbose: an update of its pharmacology and therapeutic use in diabetes mellitus. Drugs 1993 PMID: 7510610
Oki Evaluation of alpha-glucosidase inhibition by using an immobilized assay system. Biol.Pharm.Bull. 2000 PMID: 10993209
Krause Inhibition of disaccharide digestion in rat intestine by the alpha-glucosidase inhibitor aca. (BAY g 5421). Digestion 1982 PMID: 6754513