ACET

Name: ACET
Brand: Tocris Bioscience
SKU: 2728

Tocris Bioscience, part of Bio-Techne | Catalog # 2728

Citations (41)

COA / SDS

Potent kainate antagonist; displays selectivity for GluK1-containing receptors

Key Product Details

Description:	Potent kainate antagonist; displays selectivity for GluK1-containing receptors
Chemical Name:	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Purity:	≥98% (HPLC)
Molecular Weight:	429.45

View Full Technical Details for ACET

Technical Data
Citations

Biological Activity for ACET

ACET is a potent and selective GluK1 (formerly GluR5) containing kainate receptor antagonist (IC₅₀ = 7 nM) that displays selectivity over GluK2 (formerly GluR6) containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for ACET

M. Wt	429.45
Formula	C₂₀H₁₉N₃O₆S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	936095-50-0
PubChem ID	16125102
InChi Key	LCZDCKMQSBGXAH-AWEZNQCLSA-N
Smiles	O=C(C(C)=CN1C[C@@H](C(O)=O)N)N(CC2=C(C(O)=O)SC(C3=CC=CC=C3)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ACET

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	3eq. NaOH	4.29	10
	DMSO	8.59	20

Preparing Stock Solutions for ACET

The following data is based on the product molecular weight 429.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.64 mL	58.21 mL	116.43 mL
1 mM	2.33 mL	11.64 mL	23.29 mL
2 mM	1.16 mL	5.82 mL	11.64 mL
10 mM	0.23 mL	1.16 mL	2.33 mL

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References for ACET

References are publications that support the biological activity of the product.

Dargan ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 2009 PMID: 18789344
Dolman Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis J.Med.Chem. 2007 PMID: 17348638