ACHP

Name: ACHP
Brand: Tocris Bioscience
SKU: 4547

Tocris Bioscience, part of Bio-Techne | Catalog # 4547

Citations (23)

COA / SDS

Selective IKKα and IKKβ inhibitor

Key Product Details

Description:	Selective IKKα and IKKβ inhibitor
Chemical Name:	2-Amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Purity:	≥97% (HPLC)
Molecular Weight:	364.44

View Full Technical Details for ACHP

Technical Data
Citations

Biological Activity for ACHP

ACHP is a IκB kinase inhibitor (IC₅₀ values are 8.5 and 250 nM for IKKβ and IKKα respectively). Selective for IKKα and IKKβ over IKK3, Syk and MAPKKK4 (IC₅₀ values are > 20 μM). Inhibits DNA binding activity of NF-κB. Blocks NF-κB pathway in multiple myeloma cell lines; induces cell growth arrest and apoptosis. Also inhibits STAT3 signaling in NSCLC in vitro.

Technical Data for ACHP

M. Wt	364.44
Formula	C₂₁H₂₄N₄O₂
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	406208-42-2
PubChem ID	65663
InChi Key	SRVFFFJZQVENJC-IHRRRGAJSA-N
Smiles	OC1=CC=CC(OCC3CC3)=C1C2=NC(N)=C(C#N)C(C4CCNCC4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ACHP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.29	20

Preparing Stock Solutions for ACHP

The following data is based on the product molecular weight 364.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.72 mL	68.60 mL	137.20 mL
1 mM	2.74 mL	13.72 mL	27.44 mL
2 mM	1.37 mL	6.86 mL	13.72 mL
10 mM	0.27 mL	1.37 mL	2.74 mL

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References for ACHP

References are publications that support the biological activity of the product.

Murata Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 3: Orally active anti-inflammatory agents. Bioorg.Med.Chem.Lett. 2004 PMID: 15225718
Lee The IκB kinase inhibitor ACHP targets the STAT3 signaling pathway in human non-small cell lung carcinoma cells. Biomolecules 2019 PMID: 31847229
Sanda Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor. Clin.Cancer Res. 2005 PMID: 15756023