AGI 5198

Name: AGI 5198
Brand: Tocris Bioscience
SKU: 7087

Tocris Bioscience, part of Bio-Techne | Catalog # 7087

COA / SDS

Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)

Key Product Details

Description:	Potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1)
Chemical Name:	N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-Imidazole-1-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	462.56

View Full Technical Details for AGI 5198

Technical Data
Citations

Biological Activity for AGI 5198

AGI 5198 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1; IC₅₀ = 70 nM). Selective for mIDH1 over wild-type IDH1 and IDH2. Inhibits production of oncometabolite D-2 hydroxyglutarate. Attenuates growth of glioma cells containing mIDH1, but not wild-type IDH1, in vitro and in vivo. Also inhibits growth of fibrosarcoma and chondrosarcoma cells bearing mIDH1.

Compound Libraries for AGI 5198

AGI 5198 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AGI 5198

M. Wt	462.56
Formula	C₂₇H₃₁FN₄O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1355326-35-0
PubChem ID	56645356
InChi Key	FNYGWXSATBUBER-UHFFFAOYSA-N
Smiles	CC1=NC=CN1CC(=O)N(C(C(=O)NC1CCCCC1)C1=C(C)C=CC=C1)C1=CC(F)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AGI 5198

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.13	50
	ethanol	4.63	10

Preparing Stock Solutions for AGI 5198

The following data is based on the product molecular weight 462.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.32 mL	21.62 mL	43.24 mL
2.5 mM	0.86 mL	4.32 mL	8.65 mL
5 mM	0.43 mL	2.16 mL	4.32 mL
25 mM	0.09 mL	0.43 mL	0.86 mL

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References for AGI 5198

References are publications that support the biological activity of the product.

Li Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells. PLoS ONE 2015 PMID: 26368816
Badur Oncogenic R132 IDH1 mutations limit NADPH for de novo lipogenesis through (D)2-hydroxyglutarate production in fibrosarcoma cells. Cell Rep. 2018 PMID: 30355481
Rohle An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 2013 PMID: 23558169