AL 8697

Name: AL 8697
Brand: Tocris Bioscience
SKU: 4753

Tocris Bioscience, part of Bio-Techne | Catalog # 4753

COA / SDS

Potent and selective p38α inhibitor

Discontinued Product

4753 has been discontinued. View all p38 Inhibitors products.

Key Product Details

Description:	Potent and selective p38α inhibitor
Chemical Name:	N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	402.41

View Full Technical Details for AL 8697

Technical Data
Citations

Biological Activity for AL 8697

AL 8697 is a potent and selective p38α inhibitor (IC₅₀ = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.

Compound Libraries for AL 8697

AL 8697 is also offered as part of the Tocriscreen Kinase Inhibitor Library and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AL 8697

M. Wt	402.41
Formula	C₂₁H₂₁F₃N₄O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1057394-06-5
PubChem ID	25060093
InChi Key	ZVBTZTQYHOXIBC-UHFFFAOYSA-N
Smiles	CC1=C(F)C=C(C(NC4CC4)=O)C=C1C3=C(F)C2=NN=C(C(C)(C)C)N2C=C3F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for AL 8697

References are publications that support the biological activity of the product.

Aiguadé Novel triazolopyridylbenzamides as potent and selective p38&#945 inhibitors. Bioorg.Med.Chem.Lett. 2012 PMID: 22521646
Balagué Profiling of dihydroorotate dehydrogenase, p38 and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. Br.J.Pharmacol. 2012 PMID: 22229697