Alda 1

Name: Alda 1
Brand: Tocris Bioscience
SKU: 4005

Tocris Bioscience, part of Bio-Techne | Catalog # 4005

Citations (7)

COA / SDS

ALDH2 activator; cardioprotective

Key Product Details

Description:	ALDH2 activator; cardioprotective
Chemical Name:	N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
Purity:	≥99% (HPLC)
Molecular Weight:	324.16

View Full Technical Details for Alda 1

Technical Data
Citations

Biological Activity for Alda 1

Alda 1 is an activator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.

Compound Libraries for Alda 1

Alda 1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Alda 1

M. Wt	324.16
Formula	C₁₅H₁₁Cl₂NO₃
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	349438-38-6
PubChem ID	831629
InChi Key	NMKJFZCBCIUYHI-UHFFFAOYSA-N
Smiles	O=C(C3=C(Cl)C=CC=C3Cl)NCC1=CC(OCO2)=C2C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Alda 1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.42	100
	ethanol	3.24	10

Preparing Stock Solutions for Alda 1

The following data is based on the product molecular weight 324.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.42 mL	30.85 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References for Alda 1

References are publications that support the biological activity of the product.

Beretta Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitrogly. and effects of alda-1. J.Biol.Chem. 2010 PMID: 19906643
Chen An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 2008 PMID: 18787169