Alkyne-cRGD

Name: Alkyne-cRGD
Brand: Tocris Bioscience
SKU: 8042

Tocris Bioscience, part of Bio-Techne | Catalog # 8042

COA / SDS

Integrin ligand for degrader development and targeted delivery, with alkyne click handle for conjugation

Key Product Details

Description:	Integrin ligand for degrader development and targeted delivery, with alkyne click handle for conjugation
Purity:	≥95% (HPLC)
Molecular Weight:	713.78

View Full Technical Details for Alkyne-cRGD

Technical Data
Citations

Biological Activity for Alkyne-cRGD

Alkyne-cRGD is an integrin ligand for degrader development and targeted delivery. It contains an alkyne handle that enables the attachment of additional groups via copper-catalyzed azide-alkyne cycloaddition click reactions.

Technical Data for Alkyne-cRGD

M. Wt	713.78
Formula	C₃₃H₄₇N₉O₉
Single Letter Sequence	RGDYK (Modifications: Tyr-4 = D-Tyr, Lys-5 = N⁶-(1-oxo-5-hexyn-1-yl)-Lys, Lactam bridge: Arg-1 to Lys-5)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2665674-77-9
InChi Key	HWGZAFMOVGJTMT-JBXUNAHCSA-N
Smiles	NC(NCCC[C@H](NC([C@@H](NC([C@@H](CC1=CC=C(O)C=C1)N2)=O)CCCCNC(CCCC#C)=O)=O)C(NCC(N[C@@H](CC(O)=O)C2=O)=O)=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Alkyne-cRGD

Solubility

Soluble to 2mg/ml in water

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References for Alkyne-cRGD

References are publications that support the biological activity of the product.

Zheng Bifunctional compounds as molecular degraders for integrin-facilitated targeted protein degradation. J.Am.Chem.Soc. 2022 PMID: 36417563