AM 80

Name: AM 80
Brand: Tocris Bioscience
SKU: 3507

Tocris Bioscience, part of Bio-Techne | Catalog # 3507

Citations (13)

COA / SDS

RARα agonist; anticancer agent

Key Product Details

Description:	RARα agonist; anticancer agent
Alternative Names:	Tamibarotene
Chemical Name:	4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	351.44

View Full Technical Details for AM 80

Technical Data
Citations

Biological Activity for AM 80

AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED₅₀ = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.

Compound Libraries for AM 80

AM 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AM 80

M. Wt	351.44
Formula	C₂₂H₂₅NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	94497-51-5
PubChem ID	108143
InChi Key	MUTNCGKQJGXKEM-UHFFFAOYSA-N
Smiles	O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AM 80

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	17.57	50
	ethanol	17.57	50

Preparing Stock Solutions for AM 80

The following data is based on the product molecular weight 351.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.69 mL	28.45 mL	56.91 mL
2.5 mM	1.14 mL	5.69 mL	11.38 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
25 mM	0.11 mL	0.57 mL	1.14 mL

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References for AM 80

References are publications that support the biological activity of the product.

Kasamoto Am80, a retinoic acid receptor agonist, activates the cardiomyocyte cell cycle and enhances engraftment in the heart. Stem Cell Reports 2023 PMID: 37451261
Jimi RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. Int.J.Oncol. 2007 PMID: 17611697
Takenaga The effects of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol.Pharm.Bull. 2009 PMID: 19182380
Kagechika Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 1988 PMID: 3184125