AMBMP hydrochloride

Name: AMBMP hydrochloride
Brand: Tocris Bioscience
SKU: 6043

Tocris Bioscience, part of Bio-Techne | Catalog # 6043

Citations (1)

COA / SDS

Wnt canonical signaling activator; also tubulin polymerization inhibitor

Key Product Details

Chemical Name:	N⁴-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
Purity:	≥98%

View Full Technical Details for AMBMP hydrochloride

Technical Data
Citations

Biological Activity for AMBMP hydrochloride

AMBMP hydrochloride is a Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.

Technical Data for AMBMP hydrochloride

Formula	C₁₉H₁₈N₄O₃.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	2095432-75-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMBMP hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO

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References for AMBMP hydrochloride

References are publications that support the biological activity of the product.

Liu et al. A small-molecule agonist of the Wnt signaling pathway. Angew.Chem.Int.Ed.Engl., 2005;44:1987 PMID: 15724259
Wang et al. 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes. Inflamm.Res., 2016;65:61 PMID: 26613980
Fukuda et al. Tubulin is a molecular target of the Wnt-activating chemical probe. BMC Biochem., 2016;17:9 PMID: 27207629
Denicol et al. Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage. Sci.Rep., 2013;3:1266 PMID: 23405280

AMBMP hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 6043

Key Product Details

Biological Activity for AMBMP hydrochloride

Technical Data for AMBMP hydrochloride

Solubility for AMBMP hydrochloride

Dilution Calculator

Reconstitution Calculator

References for AMBMP hydrochloride

Product Documents for AMBMP hydrochloride

COA

Certificate of Analysis

SDS

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