AMG PERK 44

Name: AMG PERK 44
Brand: Tocris Bioscience
SKU: 5517

Tocris Bioscience, part of Bio-Techne | Catalog # 5517

Citations (21)

COA / SDS

Potent and selective PERK inhibitor; orally bioavailable

Key Product Details

Description:	Potent and selective PERK inhibitor; orally bioavailable
Chemical Name:	4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	561.07

View Full Technical Details for AMG PERK 44

Technical Data
Citations

Biological Activity for AMG PERK 44

AMG PERK 44 is a potent and selective PERK inhibitor (IC₅₀ = 6 nM). Exhibits >160-fold selectivity for PERK over B-Raf and GCN2, as well as a panel of 387 other kinases. Orally bioavailable.

Licensing Information

By permission of the authors

Compound Libraries for AMG PERK 44

AMG PERK 44 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AMG PERK 44

M. Wt	561.07
Formula	C₃₄H₂₈N₄O₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1883548-84-2
PubChem ID	121513867
InChi Key	RNAKBTDDCHJCMT-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=C(C3=C(N)C(C(C4=C(C5=CC=CC=C5)N(C)N(C6=CC=CC=C6)C4=O)=O)=CC=C3C)C=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AMG PERK 44

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.22	20

Preparing Stock Solutions for AMG PERK 44

The following data is based on the product molecular weight 561.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.91 mL	44.56 mL	89.12 mL
1 mM	1.78 mL	8.91 mL	17.82 mL
2 mM	0.89 mL	4.46 mL	8.91 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

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References for AMG PERK 44

References are publications that support the biological activity of the product.

Smith Discovery of 1H-pyrazol-3(2H)-ones as potent and selective inhibitors of protein kinase R-like endoplasmic reticulum kinase (PERK). J.Med.Chem. 2015 PMID: 25587754