Aminopurvalanol A

Name: Aminopurvalanol A
Brand: Tocris Bioscience
SKU: 2072

Tocris Bioscience, part of Bio-Techne | Catalog # 2072

Citations (3)

COA / SDS

Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Key Product Details

Description:	Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names:	NG 97
Chemical Name:	(2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity:	≥98% (HPLC)
Molecular Weight:	403.91

View Full Technical Details for Aminopurvalanol A

Technical Data
Citations

Biological Activity for Aminopurvalanol A

Aminopurvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 20 - 35 nM for cdk1, cdk2 and cdk5). Also inhibits ERK1 (IC₅₀ = 12.0 μM) and ERK2 (IC₅₀ = 3.1 μM) and is 3000-fold selective over a range of other protein kinases (IC₅₀ >100 μM). Arrests cell cycle at G2/M boundary (IC₅₀ = 1.25 μM), and induces apoptosis at concentrations >10 μM. Cell permeable.

Licensing Information

Sold under license from the Regents of the University of California

Compound Libraries for Aminopurvalanol A

Aminopurvalanol A is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Aminopurvalanol A

M. Wt	403.91
Formula	C₁₉H₂₆ClN₇O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	220792-57-4
PubChem ID	6604931
InChi Key	RAMROQQYRRQPDL-HNNXBMFYSA-N
Smiles	ClC1=CC(N)=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Aminopurvalanol A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.39	100

Preparing Stock Solutions for Aminopurvalanol A

The following data is based on the product molecular weight 403.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.48 mL	12.38 mL	24.76 mL
5 mM	0.50 mL	2.48 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.48 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Aminopurvalanol A

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Knockaert Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors. Chem.Biol. 2000 PMID: 10873834
Rosiana A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc.Natl.Acad.Sci.USA
Chang Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors. Chem.Biol. 1999 PMID: 10375538