Cyclin-dependent Kinase Inhibitors: Small Molecules and Peptides
40 results for "Cyclin-dependent Kinase Inhibitors Small Molecules and Peptides" in Products
40 results for "Cyclin-dependent Kinase Inhibitors Small Molecules and Peptides" in Products
Cyclin-dependent Kinase Inhibitors: Small Molecules and Peptides
Potent cdk4 and cdk6 inhibitor; brain penetrant
| Alternate Names: | Palbociclib |
| Chemical Name: | 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one isethionate salt |
| Purity: | ≥98% (HPLC) |
Cdk8 inhibitor
| Chemical Name: | 4-[(2-Phenylethyl)amino]-6-quinazolinecarbonitrile hydrochloride |
| Purity: | ≥98% |
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
| Chemical Name: | N-(4-Butyl-2-methylphenyl)acetamide |
| Purity: | ≥98% |
Cdk inhibitor
| Chemical Name: | (2R)-2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol |
| Purity: | ≥98% |
Cdk inhibitor; potently inhibits cdk1 and cdk2; also inhibits CK1; acts as molecular glue
| Chemical Name: | (2R)-2-[[9-(Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol trihydrochloride |
| Purity: | ≥99% |
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
| Alternate Names: | NG 95 |
| Chemical Name: | (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Purity: | ≥99% (HPLC) |
Potent and selective Cdk9 Degrader (PROTAC®)
| Chemical Name: | N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide |
| Purity: | ≥98% |
Cdk1 inhibitor
| Chemical Name: | 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone |
| Purity: | ≥98% (HPLC) |
Potent and selective CDK7 inhibitor; induces cell cycle arrest
| Chemical Name: | N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide |
| Purity: | ≥95% |
GSK-3β inhibitor; also inhibits cdks
| Chemical Name: | 9-Bromo-7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one |
| Purity: | ≥98% |
Cdk2 inhibitor; also potent inhibitor of aurora kinase A and B
| Chemical Name: | 4-[[6-(Cyclohexylmethoxy)-1H-purin-2-yl]amino]-N,N-diethylbenzamide |
| Purity: | ≥99% (HPLC) |
Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members
| Chemical Name: | N-[1-[[3-[[(2E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1H-pyrazole-3-carboxamide |
| Purity: | ≥98% |
SETD8 inhibitor; also CDK4 inhibitor
| Chemical Name: | 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione |
| Purity: | ≥98% |
Potent CK1 inhibitor; also inhibits cyclin-dependent kinases
| Chemical Name: | 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride |
| Purity: | ≥98% |
Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
| Alternate Names: | NG 60 |
| Chemical Name: | (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Purity: | ≥98% (HPLC) |
Selective cdk7 inhibitor
| Chemical Name: | N5-(6-Aminohexyl)-3-(1-methylethyl)-N7-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine dihydrochloride |
| Purity: | ≥99% (HPLC) |
Potent CDK1 inhibitor
| Chemical Name: | rel-N2-[(1R,2S)-2-Aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine dihydrochloride |
| Purity: | ≥98% (HPLC) |
Cdk inhibitor; potently inhibits cdk9; also inhibits MK2
| Chemical Name: | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride |
| Purity: | ≥99% (HPLC) |
Cdk inhibitor; potently inhibits cdk1, 2, 5 and 9
| Chemical Name: | 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
| Purity: | ≥99% (HPLC) |
Potent and selective ATP-competitive CDK9 inhibitor
| Chemical Name: | 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile |
| Purity: | ≥97% |
Selective cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
| Alternate Names: | NG 97 |
| Chemical Name: | (2R)-2-[[6-[(3-Amino-5-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol |
| Purity: | ≥98% (HPLC) |
Potent CDK2 inhibitor
| Alternate Names: | AUZ 454 |
| Chemical Name: | N-[4-[(2-Amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]urea |
| Purity: | ≥98% (HPLC) |
Potent cdk inhibitor
| Chemical Name: | 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol |
| Purity: | ≥98% (HPLC) |
Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
| Chemical Name: | N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide |
| Purity: | ≥99% |
Potent and selective CDK8 and CDK19 inhibitor; maintains pluripotency of mouse PSCs in culture
| Chemical Name: | N-Propyl-3-(4-pyridinyl)imidazo[1,2-b]pyridazin-6-amine |
| Purity: | ≥98% (HPLC) |
