Amlodipine besylate

Name: Amlodipine besylate
Brand: Tocris Bioscience
SKU: 2571

Tocris Bioscience, part of Bio-Techne | Catalog # 2571

(1)

Citations (5)

COA / SDS

CaV1.x blocker

Key Product Details

Chemical Name:	2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
Purity:	≥98%
Molecular Weight:	567.05 kDa

View Full Technical Details for Amlodipine besylate

Technical Data
Citations / Reviews (1)

Biological Activity for Amlodipine besylate

Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

Technical Data for Amlodipine besylate

M. Wt	567.05 kDa
Formula	C₂₀H₂₅ClN₂O₅.C₆H₆O₃S
Storage	Store at RT
Purity	≥98%
CAS Number	111470-99-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Amlodipine besylate

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Amlodipine besylate

References are publications that support the biological activity of the product.

Yoshida et al. Antiproliferative effect of Ca²⁺ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol., 2003;472:23 PMID: 12860469
Burges et al. Calcium channel blocking properties of amlod. in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol., 1987;9:110 PMID: 2434785
Toba et al. Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the NG-nitro-L-arginine methyl ester-induced hype Hypertens.Res., 2005;28:689 PMID: 16392774